Description
Buy Modafinil, modalert, provigil for sale online in Australia
Dosage Forms & Strengths
tablet: Schedule IV
- 100mg
- 200mg
Obstructive Sleep Apnea
Indicated to improve wakefulness in adults with excessive sleepiness associated with obstructive sleep apnea (OSA)
200 mg PO qAM
Doses up to 400 mg/day, given as a single dose, have been well tolerated, but there is no consistent evidence that this dose confers additional benefit beyond that of the 200 mg/day dose. Buy Modafinil, modalert, provigil for sale online in Australia
Narcolepsy
Indicated to improve wakefulness in adults with excessive sleepiness associated with narcolepsy
200 mg PO qAM
Doses up to 400 mg/day, given as a single dose, have been well tolerated, but there is no consistent evidence that this dose confers additional benefit beyond that of the 200 mg/day dose. Buy Modafinil, modalert, provigil for sale online in Australia
Shift Work Sleep Disorder
Indicated to improve wakefulness in adults with excessive sleepiness associated with shift work disorder (SWD)
200 mg PO as a single dose ~1 hr prior to patient’s work shift
Dosage Modifications
Hepatic impairment, severe: 100 mg PO qAM
Narcolepsy (Orphan)
Orphan designation of a fixed dose combination of modafinil and flecainide for narcolepsy. Buy Modafinil, modalert, provigil for sale online in Australia
Adverse Effects
>10%
Headache (45-50%)
Rhinitis (11-15%)
Decreased appetite (16%)
Nausea (11%)
Abdominal pain (12%)
1-10%
Nervousness (6-10%)
Syncope (1-5%)
Warnings
Contraindications
Hypersensitivity
Cautions
Risk of skin reactions (eg SJS, toxic necrolysis, and drug rash with eosinophilia and systemic symptoms); discontinue if rash or other hypersensitivity reactions occur. Buy Modafinil, modalert, provigil for sale online in Australia
May impair ability to operate heavy machinery and perform hazardous tasks
Not recommended in patients with angina, cardiac ischemia, recent history of myocardial infarction, left ventricular hypertrophy, or mitral valve prolapse
Use with caution in severe hepatic impairment, elderly, history of: depression, psychosis (may exacerbate psychiatric symptoms), or mania
Use with caution in patients with Tourette syndrome; stimulants may unmask ticks
May reduce effectiveness of steroidal contraceptives 1 month after discontinuation of drug therapy
Reassess degree of sleepiness frequently; if used adjunctively with continuous positive airway pressure (CPAP): Periodic assessment of CPAP compliance is necessary.
Discontinue at first sign of serious rash
Discontinue therapy if symptoms suggest angioedema or anaphylaxis
Discontinue if multiorgan hypersensitivity reaction is suspected
Pharmacology
Mechanism of Action
Unknown; not sympathomimetic; may increase dopamine levels in the brain by binding to the dopamine transporter and inhibiting dopamine reuptake.
Absorption
Peak plasma time: 2-4 hr
Distribution
Protein bound: 60%
Vd: 0.9 L/kg
Metabolism
Hepatic
Enzymes induced: CYP1A2, CYP2B6, CYP3A4; induces its own metabolism (chronic)
Enzymes inhibited: CYP2C19
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Elimination
Half-life: 15 hr
Excretion: Urine (80%)
Reviews
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