Description
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Dosage Forms & Strengths
injectable solution: Schedule III
- 10mg/mL
- 50mg/mL
- 100mg/mL
Anesthesia Induction
Load
- IV: 1-4.5 mg/kg slow IV once
- Alternatively (off-label): 0.5-2 mg/kg slow IV if adjuvant drugs (eg, midazolam) are used, OR
- IM: 6.5-13 mg/kg IM once
- Alternatively (off-label): 4-10 mg/kg IM once if adjuvant drugs (eg, midazolam) are used
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Maintenance
- 50% of IV ketamine induction dose administered PRN, OR
- 0.1-0.5 mg/min IV continuous infusion
Resistant Depression (Off-label)
Infusion: 0.5 mg/kg IV twice weekly; not to exceet 6 week; therapy >6 week not studied
Administration
IV Incompatibilities
Additive: Barbiturates, diazepam
Syringe: Barbiturates, diazepam, doxapram
IV Compatibilities
Additive: Morphine sulfate
Syringe: Bupivacaine with fentanyl, clonidine with tetracaine, lidocaine with morphine sulfate, meperidine, morphine tartrate
Y-site: Ceftazidime, propofol. Buy liquid ketamine for sale online in Australia
IV Preparation
IV infusion: Prepare 1 or 2 mg/mL solution by adding 500 mg to 500 mL or to 250 mL, respectively, of D5W or NS
IV/IM Administration
Administer IM, OR
By slow IV injection over at least 60 sec
Do not give 100 mg/mL preparation undiluted
Storage
Store at controlled room temperature
Colorless to slightly yellow solution; may darken upon prolonged exposure to light but this does not affect potency
Do not use if precipitate is present
Protect from light. Buy liquid ketamine for sale online in Australia
Warnings
Contraindications
Hypersensitivity
Conditions in which an increase in blood pressure would be hazardous
Cautions
Increases ICP (head raising may alleviate); causes hypersalivation (may be controlled with atropine/glycopyrrolate)
Not for use alone in surgery or diagnostic procedures of the pharynx, or bronchial tree, mechanical stimulation of the pharynx, larynx, or bronchial tree; avoid mechanical stimulation of the pharynx if ketamine used alone
May cause CNS depression; use caution when operating heavy machinery; do not engage in hazardous activities or operate hazardous machinery for at least 24 hr after anesthesia
May cause dependence and tolerance with prolonged use; discontinuation of long term use has been associated with a withdrawal syndrome with psychotic features. Buy liquid ketamine for sale online in Australia
Treat CNS abnormalities, CNS masses, or hydrocephalus as a relative contraindication, due to increased intracranial pressure produced by ketamine
Therapy may increase intraocular pressure, use with caution in patients with increased intraocular pressure; avoid use in patients with eye injury or other ophthalmic disorder
Glaucoma or acute globe injury may be considered a relative contraindication
Therapy may enhance sympathomimetic effect; use caution in patients with porphyria or a thyroid disorder; may consider porphyria and thyroid disorder or thyroid therapy a relative contraindication. Buy liquid ketamine for sale online in Australia
Use caution in patients with coronary artery disease, catecholamine depletion, hypertension and tachycardia; monitor cardiac function continuously in patients with increased blood pressure, heart rate, and cardiac output, thereby increasing myocardial oxygen demand
Use caution in patients with cerebrospinal fluid pressure elevation; increase in cerebrospinal fluid pressure may be associated with use
Use with caution in chronic alcoholic patients or acutely intoxicated
Use requires patient monitoring, to be administered only by experienced personnel who are not actively engaged in the procedure or surgery; in nonintubated and/or nonmechanically ventilated patients, appropriate equipment and qualified personnel should be immediately available to use appropriate equipment for rapid institution of respiratory and/or cardiovascular support. Buy liquid ketamine for sale online in Australia
Too rapid administration will cause respiratory depression
Do NOT put diazepam or barbiturates in same syringe/bag
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