Lyrica (Pregabalin)

Diabetic Peripheral Neuropathic Pain

Regular-release capsules

• Initial: 50 mg PO q8hr
• Maintenance: May increase to 100 mg PO q8hr within 1 week, as needed; not to exceed 300 mg/day

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Extended-release tablets

• Initial: 165 mg PO qDay
• Maintenance: May increase to 330 mg PO qDay within 1 week based on response and tolerability; not to exceed 330 mg PO qDay
• See also Administration

Postherpetic Neuralgia

Regular-release capsules

• Initial: 150-300 mg/day PO divided q8-12hr
• Maintenance: May increase to 300 mg/day divided q8-12hr  medicines after 1 week, as needed

Extended-release tablets

• Initial: 165 mg PO qDay
• Maintenance: May increase to 330 mg PO qDay within 1 week based on response and tolerability; not to exceed 330 mg PO qDay
• Patients experiencing insufficient pain relief following 2-4 weeks of treatment with 330 mg PO qDay and tolerate the ER tablets, may be treated with up to 660 mg PO qDay. Buy lyrica 300mg Pregabalin for sale online in Australia

Fibromyalgia

Regular-release capsules and oral solution only

Initial: 75 mg PO q12hr (150 mg/day)

Maintenance: May increase to 150mg q12hr after 1 week as needed; recommended dose is 300-400 mg/day

Owing to dose-dependent adverse reactions, doses >450 mg/day are not recommended. Buy lyrica 300mg Pregabalin for sale online in Australia

Partial Onset Seizures

Regular-release capsules and oral solution only

Indicated as adjunctive therapy for treatment of partial onset seizures

Initial: 150 mg/day PO divided q8-12hr

Maintenance: Based on clinical response and tolerability, may increase dose in weekly increments, not to exceed 600 mg/day

Efficacy of adjunctive pregabalin in patients taking gabapentin treat neuropathic pain has not been evaluated in controlled trials; consequently, no dosing recommendations can be made when pregabalin is used with gabapentin. Buy lyrica 300mg Pregabalin for sale online in Australia

Neuropathic Pain With Spinal Cord Injury

Regular-release capsules and oral solution only

Initial: 75 mg PO q12hr (150 mg/day); may increase within 1 week to 300 mg/day PO divided q12hr

If there is insufficient pain relief after 2-3 weeks and 300 mg/day dose is tolerated, may increase dose again up to 600 mg/day PO divided q12hr

Dosage Modifications

Renal impairment (capsules/oral solution)

• CrCl 30-60 mL/min

  • Decrease dose by 50% divided BID/TID

• CrCl 15-30 mL/min

  • If 150 mg/day in normal renal function: Decrease dose to 25-50 mg/day; administer qDay or BID
  • If 300 mg/day in normal renal function: Decrease dose to 75 mg/day; administer qDay or BID
  • If 450 mg/day in normal renal function: Decrease dose to 100-150 mg/day; administer qDay or BID
  • If 600 mg/day in normal renal function: Decrease dose to 150 mg/day; administer qDay or BID

• CrCl <15 mL/min

  • If 150 mg/day in normal renal function: Decrease dose to 25 mg/day; qDay
  • If 300 mg/day in normal renal function: Decrease dose to 25-50 mg/day; qDay
  • If 450 mg/day in normal renal function: Decrease dose to 50-75 mg/day; qDay
  • If 600 mg/day in normal renal function: Decrease dose to 75 mg/day; qDay

• Supplemental dosage following hemodialysis

  • 25 mg qDay regimen: Take 1 supplemental dose of 25 mg or 50 mg
  • 25-50 mg qDay regimen: Take 1 supplemental dose of 50 mg or 75 mg
  • 50-75 mg qDay regimen: Take 1 supplemental dose of 75 mg or 100 mg
  • 75 mg qDay regimen: Take 1 supplemental dose of 100 mg or 150 mg

Renal impairment (ER tablets)

• CrCl 30-60 mL/min

  • If 165 mg/day in normal renal function: Decrease dose to 82.5 mg/day
  • If 330 mg/day in normal renal function: Decrease dose to 165 mg/day
  • If 495 mg/day in normal renal function: Decrease dose to 247.5 mg/day
  • If 660 mg/day in normal renal function: Decrease dose to 330 mg/day

• CrCl <30 mL/min or hemodialysis

  • Not recommended
  • Patients should only receive capsules or oral solution

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Dosing Considerations

Conversion from capsules or oral solution (Lyrica) to ER tablets (Lyrica CR)

• Lyrica total daily dose (TDD) 75 mg/day = Lyrica CR 82.5 mg/day
• Lyrica TDD 150 mg/day = Lyrica CR 165 mg/day
• Lyrica TDD 225 mg/day = Lyrica CR 247.5 mg/day
• Lyrica TDD 300 mg/day = Lyrica CR 330 mg/day (3 × 82.5 mg tablets)
• Lyrica TDD 450 mg/day = Lyrica CR 495 mg/day (3 × 165 mg tablets)
• Lyrica TDD 600 mg/day = Lyrica CR 660 mg/day (2 × 330 mg tablets)

Administration