Name of Medicine

Temazepam. Buy Alodorm 5mg Australia – Buy Nitrazepam 5mg Australia – Alodorm 5mg for sale

6.7 Physicochemical Properties

Temazepam is a white, odourless crystalline powder; it is sparingly soluble in alcohol and freely soluble in chloroform, but insoluble in water.
APO-Temazepam (temazepam) is a 1, 4 benzodiazepine with the chemical name 7-chloro-1, 3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1-4-benzodiazepin-2-one.

Molecular formula.


Molecular weight.


Chemical structure.

CAS number.


2 Qualitative and Quantitative Composition

Each tablet contains temazepam 10 mg as the active ingredient.

List of excipients with known effect.

Lactose monohydrate. For the full list of excipients, see Section 6.1 List of Excipients.

3 Pharmaceutical Form

APO-Temazepam 10 mg are white, round, biconvex tablet, with stylised “S” on one side and plain on the other side.

5 Pharmacological Properties


5.1 Pharmacodynamic Properties


Mechanism of action.

APO-Temazepam hastens the onset of sleep and increases total sleeping time in short term use.
The exact mechanism of action of benzodiazepines has not yet been elucidated; however, benzodiazepines appear to work through several mechanisms. Benzodiazepines presumably exert their effects by binding to specific receptors at several sites within the central nervous system either by potentiating the effects of synaptic or pre-synaptic inhibition mediated by gamma-aminobutyric acid or by directly affecting the action potential generating mechanisms. Buy Alodorm 5mg Australia – Buy Nitrazepam 5mg Australia – Alodorm 5mg for sale

Clinical trials.

No data available.

5.2 Pharmacokinetic Properties



Pharmacokinetic studies have shown that APO-Temazepam is well absorbed and has a relatively short elimination half-life of approximately 10 hours (range 5-15 hours).
Peak plasma levels of the drug occur 30 to 120 minutes after administration of the tablets.

Metabolism and excretion.

With multiple dosing, steady state is obtained by the third day, and there is little or no accumulation of parent drug or metabolites.
APO-Temazepam is metabolised principally in the liver where most drug is directly conjugated to the glucuronide and excreted in the urine. Some drug is demethylated to oxazepam and eliminated as the glucuronide. The glucuronides of APO-Temazepam have no demonstrable CNS activity. Following a single oral dose, 80% of the dose appears in the urine, mostly as the conjugates, and 12% of the dose appears in the faeces.
Less than 2% of the dose is excreted unchanged in the urine. Approximately 96% of unchanged drug is bound to plasma proteins. Buy Alodorm 5mg Australia – Buy Nitrazepam 5mg Australia – Alodorm 5mg for sale

5.3 Preclinical Safety Data



No data available.


No data available.

4 Clinical Particulars


4.1 Therapeutic Indications

APO-Temazepam is indicated for:
Adjunctive therapy in the short term management of insomnia in adults.

4.3 Contraindications

Known hypersensitivity to benzodiazepines or to any of the formulation.
Chronic obstructive airways disease with incipient respiratory failure.
Sleep apnoea.
Temazepam should not be used as monotherapy to treat depression, or symptoms of anxiety associated with depression, due to a risk of suicide (see Section 4.4 Special Warnings and Precautions for Use). Buy Alodorm 5mg Australia – Buy Nitrazepam 5mg Australia – Alodorm 5mg for sale

Additional information


1 Bottle, 2 Bottles


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